Tag Archives: Endocannabinoid Regulation

Cannabinoids for COVID-19

Recently it has been discovered that cannabis, specifically CBD, can dramatically improve and reduce inflammation caused by COVID-19 leading to organ failure in advanced cases. In contrast to steroids, which can also reduce the inflammation and suppress the immune system, cannabinoids can reduce the inflammation without suppressing the immune system. It may be possible to reduce the inflammation and enable the immune system to attack the virus.

The lungs are the organ most affected by COVID-19, causing pneumonia that rapidly progresses to acute respiratory distress syndrome and can further result in respiratory failure, septic shock, or multi-organ failure, and in the most severe cases death.
There is not much published research on the effects of cannabinoids on Viral Infections, but quite a bit of anecdotal evidence exists.

Endocannabinoid System

Cannabinoids, such as THC and CBD, have been shown to have pain-relieving, sleep-inducing, and anti-inflammatory properties. Terpenes play a crucial role in Regulation of the endocannabinoid system. Cannabis may help reduce body aches, ease inflammation of the airways, and increase relaxation and enable sleep. In addition antipyretic or fever-reducing properties, due to its ability to regulate the immune system.

Mechanism

The endocannabinoid system is responsible for intercellular communication.

Mesenchymal stem cells (MSC) are small particles that are created when stem cells get multiplied. 

Exosomes are lipid bilayer-enclosed structures, released by cells and involved in intercellular communication. Exosomes-inhibiting agents can sensitize and slow infection and even reduce cancer.

Recent in-vivo and in-vitro studies have demonstrated that exosomes derived from MSC can promote regeneration and improve immune reaction processes in damaged tissues. Exosomes contain anti-inflammatory agents that can target inflamed organs. 

Researchers have already successfully loaded exosomes with various molecules. They have also succeeded in treating different tissue injuries in animal models, while significantly reducing inflammation and pathological impairment. To date, there have been hundreds of publications and several clinical studies using exosomes globally, demonstrating their therapeutic potential at different applications.

Immune Response 

It is important to understand that exacerbation of the condition is due to the excessive immune response of the body against the virus. Cannabis compounds have the ability to lower the immune system’s response without suppressing it, thereby providing better complementary treatment than steroids, which completely suppresses the immune system.

Cannabis Research 

Medical cannabis companies are joining Biotech and Biomed companies in the race to develop a cure. Previous Research on the effect of the cannabis plant on human cells can accelerate the arrival of complementary treatment.

If cannabis succeeds as a complementary treatment, it will be an achievement for the industry.