Tag Archives: Cannabis Terpene

Eucalyptol Properties

Cineol

This Monoterpene is a cyclic ether with a fresh, minty scent and a spicy yet cooling taste.

Uses 

Eucalyptol’s pleasant, spicy aroma and taste, is used in a variety of Products including; flavorings, fragrances, and cosmetics. Eucalyptus oil has natural antimicrobial and antiseptic properties used in household cleaning, natural pesticides and Mouthwash.

Source 

Eucalyptol is the dominant essential oil in eucalyptus trees. It is also commonly found in tea trees, basil, mugwort, rosemary, bay leaves, cannabis and Other Sources.

Metabolism 

Cineole, is used to increase blood circulation and relieve pain. It is fast acting, and able to cross the blood brain barrier faster than other cannabis terpenes. 

This positively charged terpene is able to cross the blood-brain barrier that separates the blood circulation from the cerebrospinal fluid. Its unique structure make it a potential drug delivery vehicle.

Antibacterial 

The antibacterial potential of cineole has been shown as an effective antibacterial agent; active against microorganisms in both planktonic and biofilm modes of growth. The terpene can be used as a natural remedy for infection associated with a wide range of microorganisms.

Anti-Fungal 

Cineole rich oil displays antifungals properties. Acting on a wide variety of common fungi. Further research has to be done to determine whether the activity is due to cineole or other terpene in the formulation.  

Anti-Inflammatory 

Cineole anti-inflammatory action has been used to treat various types of inflammation throughout the body including rhinosinusitis, pancreatitis, bowel disease, and Crohn’s disease. These diseases are characterized by inflammation of the digestive tract and ulcerative colitis. Eucalyptol has the potential to treat local and systemic inflammation.

Antioxidant 

Eucalyptol has demonstrated antioxidant properties and reduces the damage associated with cell oxidation and could potentially reduce aging by protecting against free radical damage.

Cancer

Recent studies demonstrated Induced cineole apoptosis, in two different types of leukemia. The studies demonstrate that eucalyptol has helped fight the growth of a type of cancer in humans. Researchers determined that treatment with eucalyptol is an effective strategy for treating colorectal cancer. Eucalyptol was not only anti-proliferative but also anti-cholesterol. Their results suggest that these effects work in unison to fight cancer. Linalool has also been shown to display these synergistic effects with cineole.

Alzheimer’s 

Alzheimer’s disease destroys memory through neuroinflammation. Studies have shown the anti-inflammatory effects of eucalyptol are strong enough to be a potential Alzheimer’s disease treatment.

Asthma

Inflammation induced asthma is common. Eucalyptol is known to be a very powerful treatment for asthma. Eucalyptol is a potential treatment for asthma and other lung inflammations. Researchers suggest multiple mechanisms as the source of eucalyptol’s anti-inflammatory properties and recommend cineole as a treatment for asthma. Therapy using cineole can lead to a noticeable improvement in lung function and health.

Tuberculosis

The effects of all the terpenes in Eucalyptus citriodora essential oil, and not just eucalyptol is considered to be weakly effective in alleviating the effects of tuberculosis. While this is not a cure, it may suggest that eucalyptus essential oil could be combined with other treatments for tuberculosis.

Insecticide

In addition to helping a wide range of health concerns, Eucalyptol has long been used as an insect repellent. eucalyptol is used to prevent potential health problems associated with pests.

Safety

While considered safe at natural concentrations, high concentration essential oil can be hazardous. 

Recommend inhalation and topical under 8.00% solution by volume.

May cause skin irritation.

The acute toxic potency of 1,8-cineole was relatively low (LD50 value = 3849 mg/kg).

It is recommended that all Safety Precautions be followed.

Chemical Properties 

Formula: C10H18O

Molar mass: 154.249 g/mol

Density: 922 kg/m³

Boiling point: 172 °C

Chemical Structure

Cineole Chemical Structure
Cineole Chemical Structure

What Is Limonene

Limonene takes its name from the lemon peel, but can be found in various fruits and flowers including cannabis. Its popularity stems from being the top 5 terpenes found in cannabis and has proven valuable in various applications.

Limonene exists in two  isomeric forms, D-Limonene and L-limonene. Both have different ouders and behave differently. Both forms of Limonene are classified as a monoterpenes, and degrade to produce other terpenes such as  carveol, carvone.

D-Limonene

D-Limonene has a sweet citrusy cent make it a common edible additive and can be found in many food items .Limonene is common as a dietary supplements known to promote weight loss, prevent cancer and treat bronchitis

L-Limonene

L-Limonene has a more piney, lemony, clean, turpentine-like scent. L-Limonene is a popular  ingredient in water-free hand soaps as it cleanses and leave the hands smelling fresh. 

Limonene Uses

Limonene scent characteristics makes it popular in perfumery, cosmetic and scented products 

In manufacturing, limonene is considered an effective, naturally occurring, biodegradable solvent and degreaser. It is 100% natural, environmentally friendly, non-toxic and renewable product . 

Producing Limonene

Manufacturers Extract it from the skin of citrus fruits by two methods: by spinning liquefied citrus rind (centrifugal separation) or by ‘cooking’ the rind (steam distillation). 

Limonene Toxicity

Generally Recognized As Safe (GRAS) by the FDA. D-Limonene can be used safely and effectively in a wide range of products and medications. 
Limonene itself has low toxicity, which is why it is used so widely in food-grade products. When applied to skin may sometimes cause irritation, but otherwise appears to be safe for human use.

Limonene Dermal Absorption

D-limonene can enhance Skin Absorption. It is evident that D-limonene is important factors for promoting the percutaneous absorption of indomethacin. As a possible mechanism for enhancement action of d-limonene may change the barrier structure of the stratum corneum and can help produce effective dermal drug delivery methods for  liniments, lotions, ointments, creams, dusting powders, aerosols, and transdermal patches.

Limonene Mechanism

Limone works on the endocannabinoid system and helps regulate cannabinoid uptake by the receptors CB1 and CB2. It is one of the active terpenes in the Entourage Effect 

Limonene has demonstrated the ability to reduce inflammation. One way limonene reduces inflammation is through the inhibition of angiogenesis. Angiogenesis is the formation of new blood vessels, which is an inherent component of inflammation. Thus, by inhibiting this process, limonene can help to reduce inflammation and also improve wound healing.

Studies have also shown that limonene have anti-cancer effects. Limonene increase the levels of liver enzymes involved in detoxifying carcinogens. The Glutathione S-transferase (GST) is a system which eliminates carcinogens. In addition, anti-inflammatory, antioxidant, antinociceptive, antidiabetic, antihyperalgesic and antiviral properties of limonene have been observed.

New research is uncovering how valuable Limonene is. Like limonene, there are many useful terpenes. Studying the various terpenes give us knowledge that we are eager to spread.

Chemical Properties 

Formula: C10H16

Molar mass: 136.24 g/mol

Density: 841 kg/m³

Boiling point: 176 °C

Chemical Structure 

Limonene chemical structure
Limonene